From 2010-2012 REBOUND has been developed as a European school based prevention programme at Heidelberg University Hospital with funds from DPIP and Mentor Foundation Germany. Following its first evaluation, the programme has been further optimized with the EDPQS in 2013 and subsequently been disseminated by a newly founded organization with the purpose of building a bridge between prevention research and practice. We want to present the conclusions for programme adaption that we drew from the first evaluation, explain subsequent programme adjustments and illustrate how we built structures for effective dissemination and further evaluation. How did „best practice“, evaluation data, practical and financial considerations impact the programme? Finally we will give an in-depth description of succeeding and failing implementation endeavours by comparing two prototypical schools in their struggle for providing evidence-based drug education. Which changes do we see in schools that have been working with REBOUND up to five years?